I. PATHOPHYSIOLOGY OF GLOMERULAR NEPHROPATHIES – Definition, classification
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2. BASAL membrane (BM) consists of 3 layers (lamina rara interna, lamina densa and lamina rara externa) contains 4 major components: laminin, type IV collagen, nidogen and heparan sulfate-type proteoglycans (the latter gives the negative charge of the BM) achieves an effective barrier for negatively charged large-molecular-weight proteins (> 69 kDa, > 8 nm diameter) and for albumins (GM = 67 kDa, diameter approx. 3,6 nm)
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